Part Used : น้ำจากผล
Activity : CYP1A1 INHIBITION
Solvent/Active Compound : -
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 7.81-250 mg/ml
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Type of experiment: mouse hepatic microsomes
Results: Pineapple showed the strongest inhibition on all of the evaluated P450 isoforms with median inhibitory concentrations (IC50) of 0.14, 0.55, 48.90 and 2.70 mg/ml for CYP1A1, CYP1A2, CYP2E1 and CYP3A11, respectively.
Note : Four enzymatic reactions: ethoxyresorufin O-deethylation (EROD) for CYP1A1, ethoxyresorufin O-demethylation (MROD) for CYP1A2, aniline hydroxylation (ANH) for CYP2E1, and erythromycin N-demethylation (ENDM) for CYP3A11.