ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : Pulegone (PUL)

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Intraperitoneal

Dose/Conc.(herb) : 200 mg/kg of PUL

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Haloperidol

Dose/Conc.(drug) : -

Result : Positive

Remark : - After the 30 min adaptation period, 0.032-0.125 mg/kg of haloperidol was administered, followed 10 min later by administraion of 200 mg/kg of PUL. The ambulatory activity of individual ICR mouse was continuously measured in the following experiments, and the activity during the 60 min after the final administration of the agents was also recorded. Results: haloperidol significantly suppressed the ambulation-promoting effect of 200 mg/kg of PUL in ICR mice in a dose-dependent manner (closed columns; F(3, 76) = 12.251, P < 0.05); differences from control, 0.032 mg/kg = 105.3; (P = 0.0012); 0.063 mg/kg = 122.45 (P = 0.0002); 0.125 mg/kg = 185.95 (P < 0.0001).

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