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Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 20 g/L of spearmint teaDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 40 g/L of spearmint teaDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 20 g/L of spearmint teaDuration : 25 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 40 g/L of spearmint teaDuration : 25 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 20 g/L of spearmint teaDuration : 35 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Spearmin tea/hot waterType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 40 g/L of spearmint teaDuration : 35 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : A significant change in the testicular levels of mRNA for cytochrome P450scc, cytochrome P450c17 was detects in all treated groups of male rats as compared to control after 25 days of treatment with spearmint extract. Level of P450scc and P450c17 mRNA decreased up to 60% and 55%, respectively as compared to control.
