| Synonym |
| Thai / English name |
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 10% Ethyl acetate extract of the juice of Banpeiyu, pomelo IType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : Result: The 10% ethyl acetate extract of the juice of Banpeiyu, pomelo I and grapefruit juice (GFJ) significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 76.4 and 83.9%, respectively. The extract of pomelo I was as potent as that of GFJ. The metabolism of tacrolimus itself was also inhibited by the extract of pomelo I, as well as that of GFJ. Furthermore, the inhibition of both 6beta-hydroxylation of testosterone and metabolism of tacrolimus by pomelo I and GFJ was preincubation time-dependent.Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 10% Ethyl acetate extract of the juice of Hirado Buntan, pomelo IIType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : Result: The 10% ethyl acetate extract of the juice of Buntan, pomelo II and grapefruit juice significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 67.2 and 83.9%, respectively.Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 10% Ethyl acetate extract of the juice of Tosa Buntan, pomelo IIIType of experiment : in vitroType of animal : -Type of study : Cross-sectionN(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : Result: The 10% ethyl acetate extract of the juice of Tosa Buntan, pomelo III and grapefruit juice significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 37.5 and 83.9%, respectively.Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Crude extract was prepared from squeezed juice of Citrus maximaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Crude extract prepared from juice of Citrus maxima exhibited IC50 values of 202.96 +/- 80.08 microgram/mL, compared with that of grapefruit juice crude extract at 76.96 +/- 12.28 microgram/mL. The preincubation of citrus crude extract with cytochrome P450 3A4 in the presence of NADPH led to the enhancement of cytochrome P450 3A4 inhibition. Percent inhibition at the preincubation period of 15 minutes demonstrated 50.49 +/- 3.50% compared with 19.56 +/- 6.71% at 0 minute preincubation period for Citrus maxima.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : สารกลุ่ม limonoids (limonin deepoxy และ nomilin)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: สาร limonin deepoxy และ nomilin ซึ่งเป็นสารกลุ่ม limonoids จากน้ำส้มโอยับยั้งการทำงานของ CYP3A4 ได้ ในขณะที่ nomilin เท่านั้นที่ยับยั้งการทำงานของ PgpNote : Data incomplete
Part Used : เปลือกผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Furanocoumarins (FCs) (bergamottin (BG) and 6,7-dihydroxybergamottin (DHBG)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: CYP3A inhibitory activities of yuzu slice, pomelo (buntan) marmalade and crystd. lyokan peel were very weak, 1/8-1/20 of 100% grapefruit juice.Note : The max, BG content was 5.6 microgram/g in lemon peel. The max. DHBG content was 7.2 microgram/g in crystd. grapefruit peel, about 1/30 that of raw peel. Grapefruit marmalade and crystd.grapefruit peel contained similar amts. of FCs to 100% grapefruit juice, but FCs were not detected in pomelo (buntan) marmalade or crystd. iyokan peel. Good correlation (r = 0.78) was obsd. between the FC contents of these peel products and those CYP3A inhibitory activities. Prepn. of homemade grapefruit marmalade and crystd. peel revealed that considerably lower DHBG content in these products and lower CYP3A inhibitory activity than anticipated were attributable to outflow of DHBG to broth during boiling of the raw peel. Data incomplete
