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Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : pomelo juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : Single oral 200 mg cyclosporine administered with 240 mL of pomelo juice under fasting conditions.Duration : Multiple whole blood samples were collected up to 36 h after each dose.Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : Single oral 200 mg doses of cyclosporineResult : PositiveRemark : Results: Administration of pomelo juice with cyclosporine increased the area under the curve from time 0 to the last measurable concentration (AUCt), area under the curve from time 0 to infinity (AUCinf), and maximum blood concentration (Cmax) of cyclosporine with ratios of least squares means of 119.4% (95% confidence interval [Cl], 113.4%-125.8%, 118.9% (95% Cl, 113.8%-124.3%), and 112.1% (95% Cl, 102.3%-122.8%), respectively. These results suggest that pomelo juice increases the bioavailability of cyclosporine, possibly by inhibiting CYP3A or P-gp activity (or both) in the gut wall.Note : Subject total: healthy volunteers Data incomplete
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : pomelo juiceType of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : Single oral 200 mg cyclosporine administered with 240 mL of pomelo juice under fasting conditions.Duration : Multiple whole blood samples were collected up to 36 h after each dose.Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : Single oral 200 mg doses of cyclosporineResult : PositiveRemark : Results: Administration of pomelo juice with cyclosporine increased the area under the curve from time 0 to the last measurable concentration (AUCt), area under the curve from time 0 to infinity (AUCinf), and maximum blood concentration (Cmax) of cyclosporine with ratios of least squares means of 119.4% (95% confidence interval [Cl], 113.4%-125.8%, 118.9% (95% Cl, 113.8%-124.3%), and 112.1% (95% Cl, 102.3%-122.8%), respectively. These results suggest that pomelo juice increases the bioavailability of cyclosporine, possibly by inhibiting CYP3A or P-gp activity (or both) in the gut wall.Note : Subject total: healthy volunteers Data incomplete
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Guanximiyou (Citrus grandis Osbeck vs. Guanxi)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
