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RUTACEAE Citrus maxima (Burm.f.) Merr.

Synonym

RUTACEAE Aurantium maximum Burm.
RUTACEAE Citrus decumana L.
RUTACEAE Citrus grandis (L.) Osbeck

Thai / English name

ส้มโอ*

[1-2] of 2 article(s) found

หน้า 1

[1] INHIBITION OF CYTOCHROME P450 3A4 ACTIVITY BY CRUDE EXTRACTS OF CITRUS JUICES.
SOTANAPHUN U,YAIPAKDEE P,CHAIWATPONGSAKORN S,ET AL.
THE 20th CONGRESS OF FEDERATION OF ASIAN PHARMACEUTICAL ASSOCIATIONS (FAPA), BANGKOK THAILAND, NOV. 30 - DEC 3, 2004 2004 Vol.(),238 275941 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Crude extract was prepared from squeezed juice of Citrus maxima

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Crude extract prepared from juice of Citrus maxima exhibited IC50 values of 202.96 +/- 80.08 microgram/mL, compared with that of grapefruit juice crude extract at 76.96 +/- 12.28 microgram/mL. The preincubation of citrus crude extract with cytochrome P450 3A4 in the presence of NADPH led to the enhancement of cytochrome P450 3A4 inhibition. Percent inhibition at the preincubation period of 15 minutes demonstrated 50.49 +/- 3.50% compared with 19.56 +/- 6.71% at 0 minute preincubation period for Citrus maxima.

Note : Data incomplete

[2] DIFFERENT ROLES OF PUMMELO FURANOCOUMARIN AND CYTOCHROME P450 3A5*3 POLYMORPHISM IN THE FATE AND ACTION OF FELODIPINE.
GUO L-Q,CHEN Q-Y,WANG X,ET AL.
CURR DRUG METAB 2007 Vol.8(6),623-30 361757 [Abstract]

Part Used : น้ำจากผล
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Furanocoumarins, Fruit juices of Guanximiyou (Citrus grandis Osbeck vs. Guanxi)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) :
N(Treatment) :

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) :

Duration :
Type of interaction : Pharmacokinetics

Interaction with drug : Felodipine
Dose/Conc.(drug) :

Result : Positive

Remark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.

Note : Data incomplete.

หน้า 1

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