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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pre-treated with single administration of 100% pomelo juice were significant higher than those pre-treated with water. The AUC value of tacrolimus in the rat pre-treated with 100% pomelo juice was 1.9 times larger than those pre-treated with water.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pre-treated with single administration of 100% pomelo juice were significant higher than those pre-treated with water. The AUC value of tacrolimus in the rat pre-treated with 100% pomelo juice was 1.9 times larger than those pre-treated with water.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pretreated with single administration of 50% pomelo juice were not significantly different from those pre-treated with water.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pretreated with single administration of 50% pomelo juice were not significantly different from those pre-treated with water.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations after administration of 100% pomelo juice for 3 consecutive days was higher, the repeated administration of 100% pomelo juice showed no different profile from single administration.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations after administration of 100% pomelo juice for 3 consecutive days was higher, the repeated administration of 100% pomelo juice showed no different profile from single administration.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 50% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The repeated administration of 50% pomelo juice showed higher tacrolimus blood concentrations than the single administration.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 50% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The repeated administration of 50% pomelo juice showed higher tacrolimus blood concentrations than the single administration.
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 10% Ethyl acetate extract of the juice of Banpeiyu, pomelo IType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : Result: The 10% ethyl acetate extract of the juice of Banpeiyu, pomelo I and grapefruit juice (GFJ) significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 76.4 and 83.9%, respectively. The extract of pomelo I was as potent as that of GFJ. The metabolism of tacrolimus itself was also inhibited by the extract of pomelo I, as well as that of GFJ. Furthermore, the inhibition of both 6beta-hydroxylation of testosterone and metabolism of tacrolimus by pomelo I and GFJ was preincubation time-dependent.Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN STIMULATIONSolvent/Active Compound : 10% Ethyl acetate extract of the juice of Banpeiyu, pomelo IType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : EquivocalRemark : Result: The 10% ethyl acetate extract of the juice of Banpeiyu, pomelo I had little effect on the transcellular transport of tacrolimus or [3H]digoxin across a monolayer of LLC-GA5-COL 150 cells (a porcine kidney epithelial cell line, LLC-PK1, transfected with human MDR1 cDNA and overexpressing human P-glycoprotein).Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete
