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Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : Furanocoumarins, Fruit juices of 'Guanximiyou' (Citrus grandis Osbeck vs. Guanxi)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 250 mL of fruit juices of Guanximiyou with 26-mmol (10-mg) plain tablet felodipine.Duration : Observed for 12 h after administration of drugType of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) : 26-mmol (10-mg) plain tablet felodipineResult : PositiveRemark : Results: The geometric mean and 90% confidence intervals of pharmacokinetic parameters for human oral felodipine with C. paradisi, C. grandis Osbeck vs. Guanxi, C. changshanhuyou Y.B. Chang and water were respectively as follows: peak plasma concentration (nmol.bul.L-1), 37 (32-44), 25 (21-29), 19 (16-22) and 18 (15-21); area under the plasma concentration-time curve (nmol.bul.h.bul.L-1), 118 (103-136), 84 (73-97), 64 (56-74) and 59 (51-68). Subjects showed higher heart rates with C. paradisi Macf than with C. changshanhuyou Y.B. Chang or water. *Subject total: Subjects were healthy volunteers.Note : Data incomplete.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Furanocoumarins, Fruit juices of 'Guanximiyou' (Citrus grandis Osbeck vs. Guanxi)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 250 mL of fruit juices of Guanximiyou with 26-mmol (10-mg) plain tablet felodipine.Duration : Observed for 12 h after administration of drugType of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) : 26-mmol (10-mg) plain tablet felodipineResult : PositiveRemark : Results: The geometric mean and 90% confidence intervals of pharmacokinetic parameters for human oral felodipine with C. paradisi, C. grandis Osbeck vs. Guanxi, C. changshanhuyou Y.B. Chang and water were respectively as follows: peak plasma concentration (nmol.bul.L-1), 37 (32-44), 25 (21-29), 19 (16-22) and 18 (15-21); area under the plasma concentration-time curve (nmol.bul.h.bul.L-1), 118 (103-136), 84 (73-97), 64 (56-74) and 59 (51-68). Subjects showed higher heart rates with C. paradisi Macf than with C. changshanhuyou Y.B. Chang or water. *Subject total: Subjects were healthy volunteers.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Guanximiyou (Citrus grandis Osbeck vs. Guanxi)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Guanximiyou (Citrus grandis Osbeck vs. Guanxi)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : PositiveRemark : Results: Citrus paradisi had more furanocoumarins and at higher levels than C. grandis Osbeck vs. Guanxi while C. changshanhuyou Y.B. Chang hand none, and their potencies for in vitro CYP3A inhibition were in the order as C. paradisi > C. grandis Osbeck vs. Guanxi > C. changshanhuyou Y.B. Chang.Note : Data incomplete.
Part Used : น้ำจากผลActivity : CYP3A5 INHIBITIONSolvent/Active Compound : Furanocoumarins, Fruit juices of Guanximiyou (Citrus grandis Osbeck vs. Guanxi)Type of experiment : in vitroType of animal : -Type of study : -N(Total) :N(Treatment) :Sex : -Age : -Route : -Dose/Conc.(herb) :Duration :Type of interaction : PharmacokineticsInteraction with drug : FelodipineDose/Conc.(drug) :Result : EquivocalRemark : Results: CYP3A5* polymorphism showed no significant effect on felodipine pharmacokinetics and related hemodynamic changes. This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.Note : Data incomplete.
