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Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Methanol elutes of ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methanol elutes of ethyl acetate extracts of orange juice.Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: the 60, 70, and 80% methanol eluates caused large increases of [3H}vinblastine uptake, these fractions seemed to contain the major inhibitor of P-gp.
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Methanol elutes of ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methanol elutes of ethyl acetate extracts of orange juice.Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: the 60, 70, and 80% methanol eluates caused large increases of [3H}vinblastine uptake, these fractions seemed to contain the major inhibitor of P-gp.
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : 70% Methanol elutes of ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the 70% methanol elutes of ethyl acetate extracts of orange juice.Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The 70% methanol eluate was applied to a silica gel column and eluted with hexane/acetone (5:1, 3:1, 1:1) and chloroform/methanol (1:1). The highest P-gp-inhibitory activity was found in the fourth fraction eluted with hexane/acetone (3:1).
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : 6',7'-DihydroxybergamottinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 6',7'-Dihydroxybergamottin 0 to 50 micromol/L.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: 6',7'-Dihydroxybergamottin did not inhibit P-glycoprotein at concentrations up to 50 micromol/L.Note : Conclusions: 6'7'-Dihydroxybergamottin is not responsible for the effects of grapefruit juice on cyclosporine. Because the interaction did not occur with Seville orange juice despite reduced enterocyte concentrations of CYP3A4, inhibition of P-glycoprotein activity by other compounds in grapefruit juice may be responsible. Reduced enterocyte CYP3A4 by 6',7'-dihydroxybergamottin could be important for other drugs whose bioavailability is less dependent on P-glycoprotein. Data incomplete.
