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Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Crude extract was prepared from squeezed juice of Citrus sinensisType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Crude extract prepared from juice of Citrus sinensis exhibited IC50 values of 153.20 +/- 43.83 microgram/mL, compared with that of grapefruit juice crude extract at 76.96 +/- 12.28 microgram/mL. The preincubation of citrus crude extract with cytochrome P450 3A4 in the presence of NADPH led to the enhancement of cytochrome P450 3A4 inhibition. Percent inhibition at the preincubation period of 15 minutes demonstrated 57.86 +/- 6.90% compared with 45.12 +/- 3.01% at 0 minute preincubation period for Citrus sinensis.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.2-6.0% (v/v)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Among the tropical fruit juices tested (common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit), star fruit juice showed the most potent inhibition of CYP3A.Note : Data incomplete
