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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Phenylalanine*/L-phenylalanineDose/Conc.(drug) : 500 nM [14C]phenylalanineResult : NegativeRemark : Result: No significant effect on the uptake of [14C]phenylalanine by Coaco-2 cells was found, compared with the control. This finding indicated that the effect is specific to the vinblastine efflux transporter.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Phenylalanine*/L-phenylalanineDose/Conc.(drug) : 500 nM [14C]phenylalanineResult : NegativeRemark : Result: No significant effect on the uptake of [14C]phenylalanine by Coaco-2 cells was found, compared with the control. This finding indicated that the effect is specific to the vinblastine efflux transporter.