ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 16 (M/F = 8/8)

N(Treatment) : 16 (M/F = 8/8)

Sex : Both sex

Age : 37.9 +/- 8.6 years

Route : Oral administration

Dose/Conc.(herb) : 12 ounces of commercially available calcium-fortified orange juice

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Levofloxacin

Dose/Conc.(drug) : 500 mg

Result : Positive

Remark : The coadministration of levofloxacin and calcium-fortified orange juice results in a lack of bioequivalence as compared to when it is administered with water in a fasting state. It also demonstrates the ability of nonfortified orange juice to significantly change key pharmacokinetic parameters of levofloxacin.

Note : Subjects: healthy volunteers. Each subject received the following dosage regimens in random order: (1) a single 500-mg tablet of levofloxacin with 12 ounces of water, (2) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available orange juice, and (3) a single 500-mg tablet of levofloxacin with 12 ounces of commercially available calcium-fortified orange juice.

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