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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Water layer from ethyl acetate extraction of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the water layer from ethyl acetate extraction of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : NegativeRemark : Result: No significant effect (uptake of [3H]vinblastine by Caco-2 cells) of the remaining aqueous layer after ethyl acetate extraction was seen (100 +/- 4.33% compared with the control), indicating that the active components were entirely extracted in ethyl acetate.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : Water layer from ethyl acetate extraction of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the water layer from ethyl acetate extraction of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : NegativeRemark : Result: No significant effect (uptake of [3H]vinblastine by Caco-2 cells) of the remaining aqueous layer after ethyl acetate extraction was seen (100 +/- 4.33% compared with the control), indicating that the active components were entirely extracted in ethyl acetate.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 178 +/- 5.5% in the presence of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 178 +/- 5.5% in the presence of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 228 +/- 2.8% in the presence of ethyl acetate extracts of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 228 +/- 2.8% in the presence of ethyl acetate extracts of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : diethyl ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the diethyl ether extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 203 +/- 14% in the presence of diethyl ether extracts of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : diethyl ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the diethyl ether extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 203 +/- 14% in the presence of diethyl ether extracts of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : methylene chloride extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methylene chloride extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 198 +/- 4.5% in the presence of methylene chloride extracts of orange juice, compared with the control.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : methylene chloride extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methylene chloride extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was significantly increased to 198 +/- 4.5% in the presence of methylene chloride extracts of orange juice, compared with the control.
