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Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.00001 -1.0 mg/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : NegativeRemark : None of these digoxin transport parameters were affected statistically significantly by any of the aloe vera juice concentrations applied, while verapamil (P-gp inhibitor) reduced both net digoxin flux and net digoxin Papp Net by 89% and 81%, respectively. Papp = apparent permeability coefficient, Papp Net = net Papp values
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 1.92 fold (at 0.5% w/v) and 2.54 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 2.02 fold (at 0.5% w/v) and 3.05 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxyanthracene derivatives expressed as BarbaloinType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : Zidovudine*/AZT/ZDV/AzidothymidineDose/Conc.(drug) : -Result : -Remark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxyanthracene derivatives expressed as BarbaloinType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : Lamivudine*/3TCDose/Conc.(drug) : -Result : -Remark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxyanthracene derivatives expressed as BarbaloinType of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 354* (M/F=114/240)N(Treatment) : 3 of 29Sex : Both sexAge : The majorities (40.1%) of the respondents' were between 35-44 yrs.Route : Oral administrationDose/Conc.(herb) : Half cup/glass (6.9%), 1 cup/glass (6.9%), 1-2 spoonful (10.3%) (data analyzed from 29 of 354 patients who used herbal drugs)Duration : Once daily (58.6%), many times daily (6.9%), weekly (10.3%), occasionally (24.1%) (data analyzed from 29 of 354 patients who used herbal drugs)Type of interaction : PharmacodynamicsInteraction with drug : NevirapineDose/Conc.(drug) : -Result : -Remark :Note : *Subject total: Subjects were HIV patients. **Subject treatment: 29 of 354 patients used herbal drugs. Result: A marginal improvement though not significant (p>/=0.05) in the CD4 counts (489.8+/-195.2; 419.1+/-236.2) and viral load (5117.8+/-26092.0;31136.7+/-197954.6) of HIV patients on herbal drugs compared to those who are not on herbal drugs. There are no significant associations (p>/=0.05) between socio-demographic data and use of herbal medicine. However, there is a significant difference (p
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 55N(Treatment) : 35Sex : FemaleAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Interferons*/IFN/Interferon alpha/Interferon beta/Interferon gammaDose/Conc.(drug) : -Result : PositiveRemark : The combination of interferon and herbal therapy with B complex is effective, atraumatic and simple non-surgical treatment of HPV infection.Note : Subjects: women affected by human papillomavirus (HPV) genital infection. Patients were randomized into two groups: the first group was HPV positive woman treated with other than recommended therapy (n=20), (control group); the second group was pharmacologically treated with intravaginal administration of an interferon and aloe vera-propolis in recommended scheme (n=35) with treatment of the possible fungal or bacterial genital infection prior to the specific therapy. Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1 (M/F = 0/1)N(Treatment) : 1 (M/F = 0/1)Sex : FemaleAge : 35 yrsRoute : Oral administrationDose/Conc.(herb) : 4 tablets of Aloe vera / dayDuration : 2 weeksType of interaction : PharmacodynamicsInteraction with drug : SevofluraneDose/Conc.(drug) : 0.5-1.3%Result : PositiveRemark : Compounds contained within Aloe vera can cause a reduction in prostaglandin synthesis, which may inhibit secondary aggregation of platelets. Sevoflurane inhibits thromboxane A2 formation by suppression of cyclooxygenase activity, impairs platelet aggregation, and prolongs bleeding. Although the vascularity and size of the hemangioma were the most important factors for the massive intraoperative blood loss, concomitant use of sevoflurane and Aloe vera played a contributory role. An objective causality assessment revealed that this adverse event was possible as a result of the sevoflurane and Aloe vera interaction.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case seriesN(Total) : 547N(Treatment) : *Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : Non-specifiedInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : *Subject (N) treatment: Complementary and alternative medicine (CAM) was used in 77% of our population (421.19). - 599 CAM usages that could result in drug interactions. Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ethanolic extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 g/kgDuration : 30 daysType of interaction : PharmacokineticsInteraction with drug : Daonil*/Glyburide/Glibenclamide/Diadeta/Glybenclamide/GlybenzcyclamideDose/Conc.(drug) : -Result : NegativeRemark : Aloe vera gel showed minimum activity against blood glucose and TBARS levels. Furthermore, it was found to have some neg. effects on the activity of glibenclamide.Note : Data incomplete
