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Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 1.92 fold (at 0.5% w/v) and 2.54 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 2.02 fold (at 0.5% w/v) and 3.05 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : วุ้นจากใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera gel 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: Aloe vera gel was able to significantly (p<0.05) enhance the transport of insulin across Caco-2 cell monolayers in concentrations higher than 0.5%w/v
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera whole leaf extract 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: The transport enhancement effect obtained with Aloe vera whole leaf extract on insulin was expected as it was able to decrease the transepithelial electrical resistance. (TEER) of the Caco-2 cell monolayers, which indicates opening of the tight junctions and thereby allow for increased paracellular transport across the epithelial cell layer.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : methanolType of experiment : in vivoType of animal : rabbitType of study : Open trialN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : DiltiazemDose/Conc.(drug) : -Result : -Remark : The novel buccal adhesive tablets (NBATs) exhibited a Cmax 74.6 ng/mL, Tmax 3.5 h t1/2 4.36 h. The NBATs prevented salivary scavenging effect and exhibited 82.1% bioavailability.Note : Methanol whole leavel extract of Aloe vera were used as permeation enhancer in a novel buccal adhesive tablets. Data incomplete.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Data incomplete. Data from abstract.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 7 daysType of interaction : PharmacokineticsInteraction with drug : BuspironeDose/Conc.(drug) : -Result : PositiveRemark : Rats were pretreated with Aloe vera juice for 7 days. The probe drug (buspirone) solution was placed in the isolated intestinal sac. Samples were collected at preset time points and replaced with fresh buffer. The drug content in the samples was estimated using high performance liquid chromatography medthod. The results reveal that there was a significant (p < 0.05) difference compared to control, in the transport of buspirone from the intestinal sacs which were pretreated with Aloe vera juice. It suggests that Aloe vera might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone.Note : Data incomplete Type of experiment: Rat intestine
