| Synonym |
| Thai / English name |
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 1.92 fold (at 0.5% w/v) and 2.54 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 1.92 fold (at 0.5% w/v) and 2.54 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 2.02 fold (at 0.5% w/v) and 3.05 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-5.0% w/v (5 different concentration)Duration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The R value indicate that the present of A. vera gel the insulin transport was between 2.02 fold (at 0.5% w/v) and 3.05 fold (at 5.0% w/v) higheer than the control at both pH 5.8 and pH 7.4. In contrast to the TEER results, the whole leaf extract was more effective in insulin transport enhancement compared to gel at pH 5.8 at certain concentration. The insulin transport results from this study indicate that A. vera gel and whole leaf extracts are potential intestinal absorption-enhancing agent for poorly absorbable drugs such as insulin.
Part Used : วุ้นจากใบActivity : ABSORPTION ENHANCEMENT EFFECTSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera gel 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: Aloe vera gel was able to significantly (p<0.05) enhance the transport of insulin across Caco-2 cell monolayers in concentrations higher than 0.5%w/v
Part Used : วุ้นจากใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera gelType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera gel 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: Aloe vera gel was able to significantly (p<0.05) enhance the transport of insulin across Caco-2 cell monolayers in concentrations higher than 0.5%w/v
Part Used : ใบActivity : ABSORPTION ENHANCEMENT EFFECTSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera whole leaf extract 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: The transport enhancement effect obtained with Aloe vera whole leaf extract on insulin was expected as it was able to decrease the transepithelial electrical resistance. (TEER) of the Caco-2 cell monolayers, which indicates opening of the tight junctions and thereby allow for increased paracellular transport across the epithelial cell layer.
Part Used : ใบActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Aloe vera whole leaf extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aloe vera whole leaf extract 0.10, 0.50, 1.00, 2.5 and 5.00%w/vDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : Result: The transport enhancement effect obtained with Aloe vera whole leaf extract on insulin was expected as it was able to decrease the transepithelial electrical resistance. (TEER) of the Caco-2 cell monolayers, which indicates opening of the tight junctions and thereby allow for increased paracellular transport across the epithelial cell layer.
