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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 70% ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Isoproterenol*/IsoprenalineDose/Conc.(drug) : 5 mg/kg, i.p.Result : PositiveRemark : Treatment with A. calamus 100 and 200 mg/kg, and amlodipine demonstrated marked improvement in isoproterenol-induced changes in myocardial architectures. It's protecting effects due to attenuating calcineurin activity, decreased level of NO, LDH, TBARS and increased antioxidant enzyme i.e. SOD, GPx, CAT and GST. However, treatment with A. calamus or amlodipine alone did not alter these parameters. Thus, the result shows that A. calamus attenuates isoproterenol-induced cardiomyopathy.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 70% ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Isoproterenol*/IsoprenalineDose/Conc.(drug) : 5 mg/kg, i.p.Result : PositiveRemark : Treatment with A. calamus 100 and 200 mg/kg, and amlodipine demonstrated marked improvement in isoproterenol-induced changes in myocardial architectures. It's protecting effects due to attenuating calcineurin activity, decreased level of NO, LDH, TBARS and increased antioxidant enzyme i.e. SOD, GPx, CAT and GST. However, treatment with A. calamus or amlodipine alone did not alter these parameters. Thus, the result shows that A. calamus attenuates isoproterenol-induced cardiomyopathy.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Effect of AC on vincristine-induced hot plate test Vincristine administration produced a significant decrease in the nociceptive threshold for thermal conduction heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for thermal conduction heat hyperalgesia in a dose dependent manner. Moreover, AC did not show any significant effect on the above-mentioned behavior.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Effect of AC on vincristine-induced hot plate test Vincristine administration produced a significant decrease in the nociceptive threshold for thermal conduction heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for thermal conduction heat hyperalgesia in a dose dependent manner. Moreover, AC did not show any significant effect on the above-mentioned behavior.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive dayResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for radiant heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for radiant heat hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for radiant heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for radiant heat hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for mechanical hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for mechanical hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for mechanical hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for mechanical hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for tactile mechanical allodynia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for tactile mechanical allodynia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for tactile mechanical allodynia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for tactile mechanical allodynia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
