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Part Used : เหง้าActivity : ANTICONVULSANT ACTIVITYSolvent/Active Compound : hydroalcoholic extract of Acorus calamus (HAEAC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Sodium valproate (SV) 150 mg/kg body weight was administered concurrently with the subanticonvulsant dose of HAEAC 100 mg/kg, before the convulsant (Pentylenetetrazole 60 mg/kg, ip) challenge. The pretreatment time for SV and HAEAC was 30 min.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Valproic acid*/Valproate/Sodium valproate/Valproate sodium/2-propylpentanoic acid/Dipropylacetic acidDose/Conc.(drug) : sodium valproate 150 mg/kg body weightResult : PositiveRemark : Result: There was a significant decrease in the incidence of myoclonic jerks and an increase in latencies with combination doses of SV (150 mg/kg) and HAEAC (100 mg/kg), as compared to SV alone (P<0.001)Note : On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the antiepileptic drugs (AEDs).
Part Used : เหง้าActivity : ANTICONVULSANT ACTIVITYSolvent/Active Compound : hydroalcoholic extract of Acorus calamus (HAEAC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Carbamazepine (CBZ) 10 mg/kg body weight was given along with HAEAC at a dose of 100 mg/kg, 30 min before pentylenetetrazole-induced seizures.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : Carbamazepine 10 mg/kg body weightResult : PositiveRemark : Result: There was no chenge in the incidence of myoclonic jerks and generalized clonic seizures (GCS) in rats pretreated with CBZ alone, or in combination with HAEAC (100 mg/kg). However, there was a significant increase in latencies with CBZ and HAEAC combination.Note : On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the antiepileptic drugs (AEDs).
