| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Effect of AC on vincristine-induced hot plate test Vincristine administration produced a significant decrease in the nociceptive threshold for thermal conduction heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for thermal conduction heat hyperalgesia in a dose dependent manner. Moreover, AC did not show any significant effect on the above-mentioned behavior.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Effect of AC on vincristine-induced hot plate test Vincristine administration produced a significant decrease in the nociceptive threshold for thermal conduction heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for thermal conduction heat hyperalgesia in a dose dependent manner. Moreover, AC did not show any significant effect on the above-mentioned behavior.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive dayResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for radiant heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for radiant heat hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for radiant heat hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for radiant heat hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for mechanical hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for mechanical hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for mechanical hyperalgesia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine induced decrease in the nociceptive threshold for mechanical hyperalgesia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for tactile mechanical allodynia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for tactile mechanical allodynia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant decrease in the nociceptive threshold for tactile mechanical allodynia. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced decrease in the nociceptive threshold for tactile mechanical allodynia in a dose-dependent manner. Moreover, AC per se did not show any significant effect on the above-mentioned behaviour.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 100 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant rise in the total calcium level, superoxide anion generation level and myelo peroxidase activity. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced changes in tissue biomarkers. Moreover, AC per se did not show any significant effect on the tissue biomarker changes.
Part Used : เหง้าActivity : ANALGESIC ACTIVITYSolvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : HAE-AC 200 mg/kgDuration : 14 consecutive days.Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive daysResult : PositiveRemark : Result: Vincristine administration produced a significant rise in the total calcium level, superoxide anion generation level and myelo peroxidase activity. Pre-treatment with hydroalcoholic extract of AC (100 and 200 mg/kg p.o.) attenuated the vincristine-induced changes in tissue biomarkers. Moreover, AC per se did not show any significant effect on the tissue biomarker changes.
