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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 70% ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Isoproterenol*/IsoprenalineDose/Conc.(drug) : 5 mg/kg, i.p.Result : PositiveRemark : Treatment with A. calamus 100 and 200 mg/kg, and amlodipine demonstrated marked improvement in isoproterenol-induced changes in myocardial architectures. It's protecting effects due to attenuating calcineurin activity, decreased level of NO, LDH, TBARS and increased antioxidant enzyme i.e. SOD, GPx, CAT and GST. However, treatment with A. calamus or amlodipine alone did not alter these parameters. Thus, the result shows that A. calamus attenuates isoproterenol-induced cardiomyopathy.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 70% ethanolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Isoproterenol*/IsoprenalineDose/Conc.(drug) : 5 mg/kg, i.p.Result : PositiveRemark : Treatment with A. calamus 100 and 200 mg/kg, and amlodipine demonstrated marked improvement in isoproterenol-induced changes in myocardial architectures. It's protecting effects due to attenuating calcineurin activity, decreased level of NO, LDH, TBARS and increased antioxidant enzyme i.e. SOD, GPx, CAT and GST. However, treatment with A. calamus or amlodipine alone did not alter these parameters. Thus, the result shows that A. calamus attenuates isoproterenol-induced cardiomyopathy.
