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Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : hydroalcoholic extract of Acorus calamus (HAEAC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Carbamazepine (CBZ) 10 mg/kg body weight was given along with HAEAC at a dose of 100 mg/kg, 30 min before pentylenetetrazole-induced seizures.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : Carbamazepine 10 mg/kg body weightResult : PositiveRemark : Result: There was no chenge in the incidence of myoclonic jerks and generalized clonic seizures (GCS) in rats pretreated with CBZ alone, or in combination with HAEAC (100 mg/kg). However, there was a significant increase in latencies with CBZ and HAEAC combination.Note : On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the antiepileptic drugs (AEDs).
Part Used : เหง้าActivity : ANTICONVULSANT ACTIVITYSolvent/Active Compound : hydroalcoholic extract of Acorus calamus (HAEAC)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : Carbamazepine (CBZ) 10 mg/kg body weight was given along with HAEAC at a dose of 100 mg/kg, 30 min before pentylenetetrazole-induced seizures.Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : Carbamazepine 10 mg/kg body weightResult : PositiveRemark : Result: There was no chenge in the incidence of myoclonic jerks and generalized clonic seizures (GCS) in rats pretreated with CBZ alone, or in combination with HAEAC (100 mg/kg). However, there was a significant increase in latencies with CBZ and HAEAC combination.Note : On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the antiepileptic drugs (AEDs).