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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : saponinsType of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 69 (M/F = 38/31)N(Treatment) : 46 (M/F = 25/21)Sex : Both sexAge : 54.8 +/-7.2 years (control = 53.7 +/-6.8 years)Route : Oral administrationDose/Conc.(herb) : 6 capsules each time and thrice a day after mealsDuration : 12 weeksType of interaction : PharmacodynamicsInteraction with drug : SulfonylureaDose/Conc.(drug) : -Result : PositiveRemark : Results: The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM, and the therapy was relatively safe.Note : Subject total: patients with type 2 diabetes mellitus (T2DM) not well controlled by sulfonylureas alone were randomly assigned to the treated group (46 cases) and the control group (23 cases). Dose: Trigonella foenum-graecum L. total saponins (TFGs) capsules; 0.35 g/pill, each gram of powder equals to 16 g of crude drug.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 67 yaersRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : A patient was treated with warfarin for atrial fibrillation. During treatment, an increase in international normalized ratio (INR) and her admission that she was taking a variety of natural products, to include boldo and fenugreek, led us to suspect that some of these natural products could alter the effect of warfarin. When she stopped the culpable products, the INR returned to normal after 1 week.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 20 mg/kg bwResult : PositiveRemark : Normal rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 10 mg/kg bwResult : PositiveRemark : Normal rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 5 mg/kg bwResult : PositiveRemark : Normal rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 20 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 10 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 5 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : GliclazideDose/Conc.(drug) : -Result : NegativeRemark : Type of animal: normal and diabetic rats. Results: Fenugreek-seed powder extract produced hypoglycemia when given alone and prolonged the effect of gliclazide in combination during 1-12 h in normal and diabetic rats and during 2-8 h in normal rabbits without hypoglycemic convulsions.Note : Data incomplete
