LEGUMINOSAE (FABACEAE) - PAPILIONIODEAE Trigonella foenum-graecum  L.

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 Thai / English name

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[1-1] of 1 article(s) found

 หน้า  1  

[1] EFFECTS OF FENUGREEK, GARDEN CRESS, AND BLACK SEED ON THEOPHYLLINE PHARMACOKINETICS IN BEAGLE DOGS.
AL-JENOOBI,FAHAD I.;AHAD,ABDUL;MAHROUS,GAMAL M.;ET AL.
PHARMACEUTICAL BIOLOGY (LONDON, UNITED KINGDOM) 2015 Vol.53(2),296-300  491000 [Abstract]

Part Used : เมล็ด
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : dog
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 25 g twice daily
Duration : 7 day
Type of interaction : Pharmacokinetics
Interaction with drug : Theophylline*/Aminophylline
Dose/Conc.(drug) : 200 mg
Result : Positive
Remark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.
Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.

Part Used : เมล็ด
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : dog
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 7.5 g twice daily
Duration : 7 day
Type of interaction : Pharmacokinetics
Interaction with drug : Theophylline*/Aminophylline
Dose/Conc.(drug) : 200 mg
Result : Negative
Remark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.
Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.

Part Used : เมล็ด
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : dog
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 2.5 g twice daily
Duration : 7 day
Type of interaction : Pharmacokinetics
Interaction with drug : Theophylline*/Aminophylline
Dose/Conc.(drug) : 200 mg
Result : Negative
Remark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.
Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.


 หน้า  1