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Part Used : ไม่ระบุActivity : ANTIHYPERGLYCEMIC ACTIVITYSolvent/Active Compound : saponinsType of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 69 (M/F = 38/31)N(Treatment) : 46 (M/F = 25/21)Sex : Both sexAge : 54.8 +/-7.2 years (control = 53.7 +/-6.8 years)Route : Oral administrationDose/Conc.(herb) : 6 capsules each time and thrice a day after mealsDuration : 12 weeksType of interaction : PharmacodynamicsInteraction with drug : SulfonylureaDose/Conc.(drug) : -Result : PositiveRemark : Results: The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM, and the therapy was relatively safe.Note : Subject total: patients with type 2 diabetes mellitus (T2DM) not well controlled by sulfonylureas alone were randomly assigned to the treated group (46 cases) and the control group (23 cases). Dose: Trigonella foenum-graecum L. total saponins (TFGs) capsules; 0.35 g/pill, each gram of powder equals to 16 g of crude drug.
Part Used : เมล็ดActivity : ANTIHYPERGLYCEMIC ACTIVITYSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 20 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : ANTIHYPERGLYCEMIC ACTIVITYSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 10 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : ANTIHYPERGLYCEMIC ACTIVITYSolvent/Active Compound : Water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg bwDuration : -Type of interaction : PharmacodynamicsInteraction with drug : GlimepirideDose/Conc.(drug) : 5 mg/kg bwResult : PositiveRemark : Hyperglycemic rats
Part Used : เมล็ดActivity : ANTIHYPERGLYCEMIC ACTIVITYSolvent/Active Compound : water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : GlimepirideDose/Conc.(drug) : 5-20 mg/kgResult : NegativeRemark : The combination of water extract and lower dose of glimepiride (5 mg/kg) has shown safer and potent hypoglycemic as well as antihyperglycemic activity and not created severe hypoglycemia in normal rats, while higher doses (200 mg/kg of water extract and 10 and 20 mg/kg of glimepiride) were generated lethal hypoglycemia in normal rats.Note : Data incomplete
