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Part Used : ใบ

Activity : CYP2C11 INDUCTION

Solvent/Active Compound : Terpenes

Type of experiment : in vivo

Type of animal : other

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : -

Duration : 10 days

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The selected terpenes induced P450 enzymes, as shown by a 53% higher cytochrome P450 content. Western blot studies using human CYP2E1 and rat CYP2C11 and CYP2C6 antibodies gave CYP2E, CYP2C11 and CYP2C6 immunoreactive bands of greater intensity in the test animal vs. control.

Note : Data incomplete Solvent /active compound: The terpenes chosen were 1,8-cineole, p-cymene, alpha-pinene and limonene. Type of animal: possums

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