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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : oleandrinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 ng - 5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Aliquots of digoxin-free serum pools were supplemented with a range of concentrations of either oleandrin (50 ng-5 microgram/ml), or oleander extract (0.1-10 microliter/ml). Results: Significant apparent digoxin concentrations were observed after supplementing ailquots of the drug-free serum pool with oleandrin or oleander extract.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : oleander extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.1-10 microliter/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Aliquots of digoxin-free serum pools were supplemented with a range of concentrations of either oleandrin (50 ng-5 microgram/ml), or oleander extract (0.1-10 microlitre/ml). Results: Significant apparent digoxin concentrations were observed after supplementing aliquots of the drug-free serum pool with oleandrin or oleander extract.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : oleandrinType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 20 microgramDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: mice were orally gavaged with 200 microliter of either 20 microgram of pure oleandrin (dissolved in saline containing 10% ethyl alcohol) or oleander extract diluted 1:10 with normal saline. The vehicle control contained no oleander but was normal saline containing 10% alcohol. Blood was drawn 1 and 2 h after gavage and apparent digoxin concentraions were measured using the LOCl (luminescent oxygen channeling technology) digoxin assay. Results: Mice fed with vehicle control had no apparent digoxin level at either 1 or 2 h after administration. However, when mice were fed with oleandrin or oleander extract, significant apparent digoxin concentrations were observed 1 and 2 h after feeding.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : oleander extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) :Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: mice were orally gavaged with 200 microliter of either 20 microgram of pure oleandrin (dissolved in saline containing 10% ethyl alcohol) or oleander extract diluted 1:10 with normal saline. The vehicle control contained no oleander but was normal saline containing 10% alcohol. Blood was drawn 1 and 2 h after gavage and apparent digoxin concentraions were measured using the LOCl (luminescent oxygen channeling technology) digoxin assay. Results: Mice fed with vehicle control had no apparent digoxin level at either 1 or 2 h after administration. However, when mice were fed with oleandrin or oleander extract, significant apparent digoxin concentrations were observed 1 and 2 h after feeding.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : oleandrinType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : 50 ng-5 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Three different digoxin serum pools (digoxin pool 1, 2, and 3) were prepared by combining de-identified serum specimens from patients receiving digoxin, which were submitted for therapeutic drug monitoring. Aliquots of digoxin seum pool 1 and 2 were supplemented with various amounts of pure oleandrin or oleander extract, with measurement of digoxin concentrations before and after supplementation. Results: Digoxin values were also falsely lower or elevated (bidirectional interference) when aliquots of digoxin serum pools were supplemented with oleandrin or oleander extract depending on concentration; this interference was not eliminated by free digoxin monitoring.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : oleander extractType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : 0.1-10 microliter/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: Three different digoxin serum pools (digoxin pool 1, 2, and 3) were prepared by combining de-identified serum specimens from patients receiving digoxin, which were submitted for therapeutic drug monitoring. Aliquots of digoxin seum pool 1 and 2 were supplemented with various amounts of pure oleandrin or oleander extract, with measurement of digoxin concentrations before and after supplementation. Results: Digoxin values were also falsely lower or elevated (bidirectional interference) when aliquots of digoxin serum pools were supplemented with oleandrin or oleander extract depending on concentration; this interference was not eliminated by free digoxin monitoring.
