Part Used : น้ำจากผล
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : -
Duration : 8 days
Type of interaction : Pharmacokinetics
Interaction with drug : Phenytoin*/Diphenylhydantoin/DPH
Dose/Conc.(drug) : -
Remark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.
Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC.
- Data incomplete