Synonym |
Thai / English name |
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 8 daysType of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC. - Data incomplete
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 8 daysType of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC. - Data incomplete
Part Used : น้ำจากผลActivity : BIOAVAILABILITY OFSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 8 daysType of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC. - Data incomplete
Part Used : น้ำจากผลActivity : CYP2C9 INDUCTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 8 daysType of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC. - Data incomplete