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Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : Beta-caroteneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : -Result : PositiveRemark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.Note : Data from review
Part Used : รากActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Beta-caroteneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : -Result : PositiveRemark : Beta-Carotene has accumulated Rhodamine 123, calcein AM, and doxorubicin in Caco-2 cell dose dependently. It also stimulated the efficacy of 5-Fluorouracil, doxorubicin, and eteposide in Caco-2 cells. Its impact on resistance mechanism involved downregulation of MDR1 gene expression and inhibition of p-glycoprotein transport activity in Caco-2 cells.Note : Data from review
