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GUTTIFERAE (CLUSIACEAE) Garcinia mangostana L.

Synonym

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Thai / English name

มังคุด*

[1-2] of 2 article(s) found

หน้า 1

[1] IMPACT OF SIX FRUITS-BANANA, GUAVA, MANGOSTEEN, PINEAPPLE, RIPE MANGO AND RIPE PAPAYA-ON MURINE HEPATIC CYTOCHROME P450 ACTIVITIES.
CHATUPHONPRASERT,WARANYA;JARUKAMJORN,KANOKWAN.
J APPL TOXICOL 2012 Vol.32(12),994-1001 $55305 [Full]

Part Used : น้ำจากผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 7.81-250 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse hepatic microsomes Results: The mangosteen exhibited reductions of the EROD, MROD, MROD, ENDM, and ANH activity.

Note : Four enzymatic reactions: ethoxyresorufin O-deethylation (EROD) for CYP1A1, ethoxyresorufin O-demethylation (MROD) for CYP1A2, aniline hydroxylation (ANH) for CYP2E1, and erythromycin N-demethylation (ENDM) for CYP3A11.

[2] INHIBITORY ACTIVITIES OF THAI MEDICINAL PLANTS WITH PROMISING ACTIVITIES AGAINST MALARIA AND CHOLANGIOCARCINOMA ON HUMAN CYTOCHROME P450.
WIRIYAPORN SUMSAKUL,WIRATCHANEE MAHAVORASIRIKUL,KESARA NA-BANGCHANG
PHYTOTHER RES 2015 Vol.29(),1926-33 $60695 [Full]

Part Used : เปลือกผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

หน้า 1

EN

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