ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : CYP2E1 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 7.81-250 mg/ml

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse hepatic microsomes Results: The ripe papaya decreased the EROD and ANH activities, with no effect on the ENDM activity.

Note : Four enzymatic reactions: ethoxyresorufin O-deethylation (EROD) for CYP1A1, ethoxyresorufin O-demethylation (MROD) for CYP1A2, aniline hydroxylation (ANH) for CYP2E1, and erythromycin N-demethylation (ENDM) for CYP3A11.

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