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CUCURBITACEAE Momordica charantia L.

Synonym

CUCURBITACEAE Momordica elegans Salisb.
CUCURBITACEAE Momordica indica L.
CUCURBITACEAE Momordica operculata Vell.

Thai / English name

มะระขี้นก*

[1-3] of 3 article(s) found

หน้า 1

[1] COMPLEMENTARY AND COMPARATIVE STUDY ON HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITY OF VARIOUS EXTRACTS OF EUGENIA JAMBOLANA SEED, MOMORDICA CHARANTIA FRUITS, GYMNEMA SYLVESTRE, AND TRIGONELLA FOENUM GRAECUM SEEDS IN RATS.
MUKESH YADAV,AMITA LAVANIA,RADHA TOMAR,ET AL.
APPL BIOCHEM BIOTECHNOL 2010 Vol.160(),2388-400 $41419 [Full]

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 20 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 10 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 5 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 20 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 10 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 5 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

[2] ENHANCING ACTIVITY OF ANTICANCER DRUGS IN MULTIDRUG RESISTANT TUMORS BY MODULATING P-GLYCOPROTEIN THROUGH DIETARY NUTRACEUTICALS.
MUHAMMAD KHAN,AMARA MARYAM,TAHIR MEHMOOD,ET AL.
ASIAN PAC J CANCER PREV 2015 Vol.16(16),6831-9 $59875 [Full]

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Kuguacin J

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin J

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Vinblastine*/VLB
Dose/Conc.(drug) : -

Result : Positive

Remark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.

Note : Data from review

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : Kuguacin J

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin J

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -

Result : Positive

Remark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.

Note : Data from review

[3] DRUG INTERACTIONS WITH GARLIC AND GINGER SUPPLEMENTS.
ABOU-DIWAN,CHARBEL;RITCHIE,JAMES.
HERBAL SUPPLEMENTS 2011 Vol.(),333-50 $60025 [Full]

Part Used : ผล
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Case report

N(Total) : 1
N(Treatment) : 1

Sex : Female
Age : -

Route : Oral administration
Dose/Conc.(herb) : a curry containing garlic and bitter melon

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Chlorpropamide
Dose/Conc.(drug) : -

Result : Positive

Remark : Garlic may also enhance the effect of antidiabetic drugs such as chlorpropamide. It was reported that a woman on chlorpropamide therapy who ate a curry containing garlic and Momordica charantia experienced an enhanced antidiabetic response.

Note : Data incomplete, data from review article

หน้า 1

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