Synonym |
Thai / English name |
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : Kuguacin JType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin JDuration : -Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : -Result : PositiveRemark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.Note : Data from review
Part Used : ผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Kuguacin JType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin JDuration : -Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : -Result : PositiveRemark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.Note : Data from review