ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : P-GLYCOPROTEIN INHIBITION

Solvent/Active Compound : crude extract

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 11.89+/-0.65 microgram/ml.

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The results showed that lime juice extract strongly inhibited CYP3A4 catalytic activity with an IC50 value of 11.89+/-0.65 microgram/ml. The 1-hour accumulation or rhodamine 123 in Caco-2 cells was significantly increased in the presence of lime juice extract. The apical to basolateral transport of digoxin was significantly increased, whereas the basolateral to apical transport was significantly decreased, indicating that this extract can inhibit efflux transporters, involving Pgp, in Caco-2 cells.

Note : Data incomplete

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