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Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : bergamottinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : ImperatoninType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : -Remark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : crude extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 11.89+/-0.65 microgram/ml.Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The results showed that lime juice extract strongly inhibited CYP3A4 catalytic activity with an IC50 value of 11.89+/-0.65 microgram/ml. The 1-hour accumulation or rhodamine 123 in Caco-2 cells was significantly increased in the presence of lime juice extract. The apical to basolateral transport of digoxin was significantly increased, whereas the basolateral to apical transport was significantly decreased, indicating that this extract can inhibit efflux transporters, involving Pgp, in Caco-2 cells.Note : Data incomplete
Part Used : น้ำจากผลActivity : CYP3A4 INHIBITIONSolvent/Active Compound : สารกลุ่ม coumarins, limonoids, และ flavonoids, สาร limettin, isopimpinellin, oxypeucedanin hydrateType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: สารกลุ่ม coumarins, limonoids, และ flavonoids สาร limettin และ isopimpinellin ที่แยกได้จากน้ำมะนาว และ oxypeucedanin hydrate มีฤทธิ์ยับยั้งการทำงานของ CYP3A4Note : Data incomplete
