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Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : Methanolic extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The methanolic extract competitively inhibited CYP3A4 (IC50 = 5 microgram/mL) with an inhibition constant (Ki) of 3.4 microgram/mL while non-competitive inhibition of CYP1A2 (IC50= 0.8 microgram/mL, Ki = 0.5 microgram/mL). The strong inhibition of CYP3A4 and 1A2 by beal extract could results in potential herb-drug interaction.Note : Data incomplete
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : marmelosinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Marmelosin was the most potent inhibitor for both CYP3A4 and 1A2 with IC50 of 2.4 microM and 0.2 microM, respectively. Similar to the extract, marmelosin was a competitive inhibitor (Ki=0.9 microM) of CYP3A4 and non-competitive inhibitor (Ki = 0.3 microM) of CYP1A2. The strong inhibition of CYP3A4 and 1A2 by marmelosin could results in potential herb-drug interaction.Note : Data incomplete