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RUTACEAE Aegle marmelos (L.) Correa ex Roxb.

Synonym

none ...

Thai / English name

มะตูม*

[1-1] of 1 article(s) found

หน้า 1

[1] INHIBITORY EFFECTS OF AEGLE MARMELOS AND ITS CONSTITUENTS ON CYP3A4 AND CYP1A2 IN HUMAN LIVER MICROSOMES.
VK MANDA,B AVULA,IA KHAN,ET AL.
PLANTA MED 2015 Vol.81(),PP10 489704 [Abstract]

Part Used : ผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : Methanolic extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The methanolic extract competitively inhibited CYP3A4 (IC50 = 5 microgram/mL) with an inhibition constant (Ki) of 3.4 microgram/mL while non-competitive inhibition of CYP1A2 (IC50= 0.8 microgram/mL, Ki = 0.5 microgram/mL). The strong inhibition of CYP3A4 and 1A2 by beal extract could results in potential herb-drug interaction.

Note : Data incomplete

Part Used : ผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : marmelosin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Marmelosin was the most potent inhibitor for both CYP3A4 and 1A2 with IC50 of 2.4 microM and 0.2 microM, respectively. Similar to the extract, marmelosin was a competitive inhibitor (Ki=0.9 microM) of CYP3A4 and non-competitive inhibitor (Ki = 0.3 microM) of CYP1A2. The strong inhibition of CYP3A4 and 1A2 by marmelosin could results in potential herb-drug interaction.

Note : Data incomplete

Part Used : ผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : marmesinin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Marmesinin showed a moderate inhibition of CYP3A4 (IC50 of 29 microM; Ki 23 microM, while no inhibition of CYP1A2 was seen.

Note : Data incomplete

Part Used : ผล
Activity : CYP1A2 INHIBITION

Solvent/Active Compound : argeline

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Argeline was a very weak inhibitor of CYP3A4 (IC50 =76 microM) and showed no inhibition of CYP1A2.

Note : Data incomplete

หน้า 1

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