| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : AradaibType of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : Coadministration with drugType of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : PositiveRemark : The mean AUC values after administration with water (control) and arabaib were 7.52 +/- 0.87 and 2.60 +/- 0.24, mg.h/L, respectively. The corresponding mean Cmax values were 553 +/- 17.8 and 184 +/- 21.3 mg/L and the corresponding Tmax values were 3.0 +/- 1.0 and 3.2 +/- 1.2 h for control and aradaib, respoectively. The results indicate a statistically significant reduction in the AUC and Cmax of chloroquine as a result of a coadministration with the aradaib beverages.Note : Data incomplete.
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 6N(Treatment) : 6Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Ibuprofen*/Para-isobutylhydratropic acidDose/Conc.(drug) : 400 mgResult : PositiveRemark : Subjects: healthy volunteers were administered ibuprofen tablet with the Tamarindus indica L. fruit extract. Results: Tamarindus indica L. fruit ext. significantly increased the bioavailability of lbuprofen.Note : Data incomplete
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : Tamarindus indica L. fruit extractType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 6N(Treatment) : 6Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : -Result : PositiveRemark : - The results indicated there was a statistically significant increase in the plasma levels of aspirin and salicylic acid, respectively, when the meal containing Tamarindus indica fruit extract was administered with the aspirin tablets that when taken under fasting state or with the meal without the fruit extract. - The Cmax, AUC0-6h, and t1/2 for aspirin increased from 10.04+/-0.1 mg/ml to 28.62+/-0.21 mg/ml (P<0.05); 14.03+/-0.11 mg/ml. h to 86.51+/-0.21 mg/ml.h (P<0.085) and 1.04+/-0.12 h to 1.50+/-0.44 h (P<0.05) respectively. There was no change in the tmax (0.50+/-0.17 h) but there was a decrease in the Kel from 0.633+/-0.22 to 0.463+/-0.29 (P<0.05). Similarly, the Cmax, AUC 0-6 h and Kel for salicylic acid rose from 43.84+/-0.21 mg/ml to 68.19+/-0.71 mg/ml (P<0.05); 171.59+/-0.07 mg/ml.h to 266.22+/-0.21 mg/ml/.h (P<0.05) and 7.37+/-0.29 to 19.30+/-0.21 (P<0.05), respectively. The tmax decreased from 2.0 +/-0.18 h to 1.0+/-0.08 h (P<0.05) and t1/2 from 0.25+/-0.21 h to 0.184+/-0.11 h (P<0.05).Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 6N(Treatment) : -Sex : MaleAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Chloroquine*/Chloroquine sulphateDose/Conc.(drug) : 600 mgResult : -Remark : The results indicate a statistically significant reduction in the area under the plasma concentrations versus time curve (AUC) and the peak plasma concentration (Cmax) of chloroquine as a result of a co-administration with each of the three beverages (T. indica, H. sabdariffa and C. limetta).Note : - Data from review - Abbreviation HSE Hibiscus sabdariffa Extract HCT hydrochlorothiazide
