ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : CYP3A4 INHIBITION

Solvent/Active Compound : methanol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 1.65 mg/ml of water extract powder

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Erythromycin*/Erythrocin

Dose/Conc.(drug) : -

Result : Positive

Remark : Among the MeOH-soluble fractions, Piper nigrum leaf showed the highest inhibitory activity against CYP3A4 (91.7%) and Punica granatum against CYP2D6 (98.1%). The water extract MeOH-soluble fraction showed inhibitory activity more than 70% were fractionated with EtOAc. The most potent inhibitory activity against CYP3A4 (IC50 avlue of 25 mg/ml) was found for the extract of Pi. nigrum leaf, while that of Catharanthus roseus showed the most potent inhibitory effect against CYP2D6 (IC50 value of 11 mg/ml).

Note : Ketoconazole and quinidine (1 micromolar) were used as the positive control for CYP3A4 and CYP2D6, respectively.

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