Part Used : ไม่ระบุ
Activity : CYP2C11 INHIBITION
Solvent/Active Compound : Maslinic acid
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 1.25-100 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Remark : Type of experiment: In rat liver microsomes.
- Maslinic acid inhibited CYP2C11 mediated 4-hydroxytolbulamide formation (IC20 = 11.9 micromolar).
- Inhibited rat liver CYP2C11 47.9%.
Note : - Maslinic acid would have a low potential to cause the possible toxicity and drug interations involving CYP enzymes.