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Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : capsaicinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.3 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : NegativeRemark :Note : The results indicated that after 7 days of low or middle dose of capsaicin (0.3 or 1.0 mg/kg), the blood concentration of cyclosporine (CyA) was not significantly changed compared with that of vehicle treated rats, whereas the blood concentration of CyA in high dose group (3.0 mg/kg) was significantly increased. The total clearance (CL/F) of CyA was decreased, and the bioavailability was significantly increased to about 1.44-fold of that in vehicle-treated rats after 7 days of high dose CAP treatment. At this time, the P-glycoprotein and CYP3A1/2 in the liver and intestine were decreased at both the mRNA and protein levels.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : capsaicinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3.0 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark :Note : The results indicated that after 7 days of low or middle dose of capsaicin (0.3 or 1.0 mg/kg), the blood concentration of cyclosporine (CyA) was not significantly changed compared with that of vehicle treated rats, whereas the blood concentration of CyA in high dose group (3.0 mg/kg) was significantly increased. The total clearance (CL/F) of CyA was decreased, and the bioavailability was significantly increased to about 1.44-fold of that in vehicle-treated rats after 7 days of high dose CAP treatment. At this time, the P-glycoprotein and CYP3A1/2 in the liver and intestine were decreased at both the mRNA and protein levels.
Part Used : -Activity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : capsaicinType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1.0 mg/kgDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : NegativeRemark :Note : The results indicated that after 7 days of low or middle dose of capsaicin (0.3 or 1.0 mg/kg), the blood concentration of cyclosporine (CyA) was not significantly changed compared with that of vehicle treated rats, whereas the blood concentration of CyA in high dose group (3.0 mg/kg) was significantly increased. The total clearance (CL/F) of CyA was decreased, and the bioavailability was significantly increased to about 1.44-fold of that in vehicle-treated rats after 7 days of high dose CAP treatment. At this time, the P-glycoprotein and CYP3A1/2 in the liver and intestine were decreased at both the mRNA and protein levels.
