| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Black pepperType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=4.1 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Black pepperType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=12.1 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : White pepperType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=1.0 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : White pepperType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=3.2 microgram/ml
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : TrikatuType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 g/kg dailyDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : The mean plasma concentrations of pefloxacin were consistently lower in trikatu treated goats up to 2 h compared with control animal. The bioavailability of the drug was also significantly higher in trikatu treated goats (44.18+/-2.90% against 38.33 +/-1.80% in control animals). Prior treatment of the goats with trikatu significantly reduced the elimination half-life (t1/2Beta) and the zero time intercept of the elimination phase. The indicators of drug distribution in the body i.e. apparent volume of distribution and volume of distribution based on the zero time plasma drug concentration intercept of the elimination phase were significantly higher in the trikatu treated goats.Note : Trikatu prepared from equal parts of Piper longum, Piper nigrum and Zingiber officinale. Type of animal = goat
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : EthanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : piperine ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : piperine ethanol 10 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : DMSO (Dimethyl Sulfoxide)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : ผลActivity : DRUG INTERACTIONSolvent/Active Compound : piperine DMSOType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : piperine DMSO 10 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Trikatu laboratory formulation / EthanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micrograms/mLDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).
