Part Used : ผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : Trikatu
Type of experiment : in vivo
Type of animal : other
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 2 g/kg daily
Duration : 15 days
Type of interaction : Pharmacokinetics
Interaction with drug : Pefloxacin
Dose/Conc.(drug) : -
Remark : The mean plasma concentrations of pefloxacin were consistently lower in trikatu treated goats up to 2 h compared with control animal. The bioavailability of the drug was also significantly higher in trikatu treated goats (44.18+/-2.90% against 38.33 +/-1.80% in control animals). Prior treatment of the goats with trikatu significantly reduced the elimination half-life (t1/2Beta) and the zero time intercept of the elimination phase. The indicators of drug distribution in the body i.e. apparent volume of distribution and volume of distribution based on the zero time plasma drug concentration intercept of the elimination phase were significantly higher in the trikatu treated goats.
Note : Trikatu prepared from equal parts of Piper longum, Piper nigrum and Zingiber officinale.
Type of animal = goat
