| Synonym |
| Thai / English name |
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : ApigeninType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : MyricetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : 100% methanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : - Dried, plant samples (~10 g) were extracted in 100 mL of 100% methanol (MeOH) evernight. - Plant extracts were screened for the ability to induce CYP1A2 and CYP3A4. 1A2DRE (human XRECYP1A2-luciferase promoter) and DPX2 (human PXRCYP3A4-luciferase promoter) in hepatoma cell lines. Criteria for "positive" plant samples was set at ~40% of the response seen for the prototype inducers, i.e., > 40-fold in luciferase activity for CYP1A2 and > 3.5-fold increase for CYP3A4. - Plant extracts were screened for inhibitiory activity towards CYP1A2, CYP3A4, and CYP2D6 using enzyme-selective model substrates in human liver microsomes. Methoxyresorufin (MR) was used to assess CYP1A2 activity, 7-benzyloxyquinoline (7-BQ) was used to assess CYP3A4 activity and 7-methoxy-4-(aminomethyl)-coumarin (MAMC) was used to assess CYP2D6 activity. Extracts showing >50% inhibition at half-saturating and/or saturating substrate concentrations were deemed inhibitory.
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : guava leaves extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The extract of guava leaves (GvEx) inhibited CYP2C8, CYP2C9 and CYP3A4 (IC50: 18.16 micrograms/mL, 28.00 micrograms/mL, 19.92 micrograms/mL, respectively). In contrast, quercetin contained at 3.5% in the GvEx had a more than tenfold higher inhibitory activity in these P 450 tests (IC50: 0.59 micrograms/mL, 1.62 micrograms/mL, 1.50 micrograms/mL). The GvEx inhibited CYP2D6, CYP2C19, CYP2B6 and CYP1A2 several fold weaker than quercetin.Note : Data in complete
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : guava teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Bansoreicha (a guava tea product) did not inhibit these P 450 enzymes.Note : Data in complete
