ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : guava leaves extract

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The extract of guava leaves (GvEx) inhibited CYP2C8, CYP2C9 and CYP3A4 (IC50: 18.16 micrograms/mL, 28.00 micrograms/mL, 19.92 micrograms/mL, respectively). In contrast, quercetin contained at 3.5% in the GvEx had a more than tenfold higher inhibitory activity in these P 450 tests (IC50: 0.59 micrograms/mL, 1.62 micrograms/mL, 1.50 micrograms/mL). The GvEx inhibited CYP2D6, CYP2C19, CYP2B6 and CYP1A2 several fold weaker than quercetin.

Note : Data in complete

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