Part Used : ดูหมายเหตุ
Activity : SIGNAL TRANSDUCTION MODULATION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 82 g/kg
Duration : 8 weeks
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : 5 mg
Remark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.
Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively.
Part used: cotyledon