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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 15N(Treatment) : -Sex : Both sexAge : 78+-/6 yrs.Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: flaxseed + Any oral drug = Decreased absorption (No. Potential or Possible Interactions = 9 of 45)Note : Subject total: Subjects were veterans over the age of 65 years who are frail and have complex medical and psychosocial problems.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 8% dietary flaxseed oilDuration : 4 weeks?Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : TrastuzumabDose/Conc.(drug) : 2.5 mg/kg, twice daily, ip.Result : -Remark : Control tumors significantly grew 187%, TRAS2.5 treated tumors did not change, while TRAS5, FO + TRAS2.5 and FO + TRAS5 treated tumors significantly regressed 75%, 89% and 84%, respectively, after 4 weeks treatment. Two weeks after stopping TRAS treatment while continuing on same diet, tumor size in FO + TRAS2.5 group was 87% lower than in TRAS2.5 group and was not different from TRAS5 group with or without FO. Combined TRAS2.5 treatment with FO caused a significantly lower tumor cell proliferation and higher apoptosis compared to TRAS2.5 treatment alone and showed similar effects to TRAS5 treatment with or without FO.Note : Type of experiment: Ovariectomized athymic mice were separated into five treatment groups such that tumor size and body weight were similar among treatment groups: Control group was fed the basal diet (BD); TRAS2.5 group and TRAS5 group received 2.5 and 5.0 mg/kg body weight Trastuzumab (TRAS) intraperitoneal injections twice weekly after loading doses of 5 and 10 mg/kg, respectively, and fed the BD; FO + TRAS2.5 group and FO + TRAS5 group received, respectively, the same treatment as TRAS2.5 group and TRAS5 group but fed the flaxseed oil (FO), diet.
Part Used : ดูหมายเหตุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : secoisolariciresinol diglucoside (SDG) lignanType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : SDG 1 g/kg dietDuration : 8 weeksType of interaction : PharmacokineticsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : Flaxseee oilType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Flaxseed oil 38.5 g/kg dietDuration : 8 weeksType of interaction : PharmacodynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : Flaxseee oilType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Combined SDG 0.1 g/kg diet and flaxseed oil 38.5 g/kg dietDuration : 8 weeksType of interaction : PharmacodynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
