ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ดูหมายเหตุ

Activity : ESTROGEN RECEPTOR BINDING EFFECT

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : mouse

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 82 g/kg

Duration : 8 weeks

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM

Dose/Conc.(drug) : 5 mg

Result : Positive

Remark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.

Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon

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