Part Used : น้ำมัน
Activity : CELL PROLIFERATION INHIBITION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : mouse
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 8% dietary flaxseed oil
Duration : 4 weeks?
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Trastuzumab
Dose/Conc.(drug) : 2.5 mg/kg, twice daily, ip.
Remark : Control tumors significantly grew 187%, TRAS2.5 treated tumors did not change, while TRAS5, FO + TRAS2.5 and FO + TRAS5 treated tumors significantly regressed 75%, 89% and 84%, respectively, after 4 weeks treatment. Two weeks after stopping TRAS treatment while continuing on same diet, tumor size in FO + TRAS2.5 group was 87% lower than in TRAS2.5 group and was not different from TRAS5 group with or without FO. Combined TRAS2.5 treatment with FO caused a significantly lower tumor cell proliferation and higher apoptosis compared to TRAS2.5 treatment alone and showed similar effects to TRAS5 treatment with or without FO.
Note : Type of experiment: Ovariectomized athymic mice were separated into five treatment groups such that tumor size and body weight were similar among treatment groups: Control group was fed the basal diet (BD); TRAS2.5 group and TRAS5 group received 2.5 and 5.0 mg/kg body weight Trastuzumab (TRAS) intraperitoneal injections twice weekly after loading doses of 5 and 10 mg/kg, respectively, and fed the BD; FO + TRAS2.5 group and FO + TRAS5 group received, respectively, the same treatment as TRAS2.5 group and TRAS5 group but fed the flaxseed oil (FO), diet.
