| Synonym |
| Thai / English name |
Part Used : ดูหมายเหตุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : ดูหมายเหตุActivity : ANTITUMOR ACTIVITYSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : ดูหมายเหตุActivity : TUMOR PROMOTION INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : ดูหมายเหตุActivity : ESTROGEN RECEPTOR BINDING EFFECTSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : ดูหมายเหตุActivity : SIGNAL TRANSDUCTION MODULATIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 82 g/kgDuration : 8 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : 5 mgResult : PositiveRemark : FC reduced the growth of ER + human breast tumours at low circulating E2, alone and combined with TAM, in part through modulation of ER2 and growth factor-mediated signalling pathways; it may substitute for flaxseed in increasing the effectiveness of TAM.Note : Type of experiment: ovariectomised mice with established oestrogen receptor (ER)-positive breast tumours (MCF-7) were treated as follows: groups 1 and 2 were fed the basal diet (BD, control) and n-3 fatty acid-rich cotyledon fraction of flaxseed (FC) diet (82 g FC/kg), respectively. Groups 3 and 4 with tamoxifen (TAM) implants (5 mg) were fed the BD and FC diet, respectively. Part used: cotyledon
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : secoisolariciresinol diglucoside (SDG) lignanType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : SDG 1 g/kg dietDuration : 8 weeksType of interaction : PharmacokineticsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : Flaxseee oilType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Flaxseed oil 38.5 g/kg dietDuration : 8 weeksType of interaction : PharmacodynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : Flaxseee oilType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Combined SDG 0.1 g/kg diet and flaxseed oil 38.5 g/kg dietDuration : 8 weeksType of interaction : PharmacodynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : All treatments reduced growth of TAM-treated tumors by reducing cell proliferaton, expression of genes, and proteins involved in the ER- and growth factor- mediated signaling pathways with flaxseed oil having the greatest effect in increasing apoptosis compared with TAM treatment alone.Note : Data incomplete.
